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11 Experimenteller Teil

271

Nach Umkristallisation aus EE werden 102 mg (36%) von 4-Fluor-N’-(4-(2-oxo-2H-

chromen-3-yl)thiazol-2-yl)benzhydrazid

338 als gelber Feststoff erhalten.

H-NMR (300 MHz, DMSO-d

= 10.99 (s, 1H, 5-NH), 9.78 (s, 1H, 6-NH), 8.96 (s,

1H, 11-H), 8.03–7.98 (

m, 2H, 3-H), 7.87 (d, 1H, 13-H, J = 7.5 Hz), 7.70 (s, 1H, 9-H),

7.60 (

dd, 1H, 15-H, J = 7.8, 15.2 Hz), 7.45–7.36 (m, 4H, 2-H, 14-H, 16-H) ppm.

C-NMR (75 MHz, DMSO-d

= 172.1 (7-C), 165.8 (1-C), 158.7 (CONR), 152.2

(COOR), 149.5 (17-C), 146.2 (11-C), 144.0 (8-C), 135.8 (4-C), 131.1 (10-C), 130.1

(3-C), 128.9 (15-C), 127.7 (13-C), 125.5 (14-C), 124.6 (16-C), 120.4 (12-C), 115.6 (2-

C), 110.0 (9-C) ppm.

11.15.2.8 Herstellung von 2-Fluor-N’-(4-phenylthiazol-2-yl)benzhydrazid (339)

Nach Umkristallisation aus EE werden 68 mg (43%) von 2-Fluor-

N’-(4-phenylthiazol-

2-yl)benzhydrazid

339 als farbloser Feststoff erhalten.

H-NMR (300 MHz, DMSO-d

= 10.71 (s, 1H, 7-NH), 9.74 (s, 1H, 8-NH), 7.86 (d,

2H, 13-H, J = 4.8 Hz), 7.66–7.64 (

m, 2H, 4-H, 6-H), 7.38–7.28 (m, 6H, 2-H, 3-H, 11-

H, 14-H, 15-H) ppm.

C-NMR (75 MHz, DMSO-d

= 172.4 (8-C), 164.5 (CONR), 159.6 (1-C), 151.1

(10-C), 135.1 (5-C), 133.5 (12-C), 130.3 (3-C), 128.9 (14-C), 127.9 (15-C), 126.0 (12-

C), 125.1 (4-C), 122.6 (2-C), 116.8 (6-C), 103.7 (11-C) ppm.

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Sharp R-120DW Manuale Utente Pagina 295